A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.
نویسندگان
چکیده
[chemical reaction: see text]. Three new ent-trachylobane diterpenoids (1-3) were isolated and structures elucidated from Mitrephora glabra Scheff. (Annonaceae). Mitrephorone A (1) possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachylobanes. All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent.
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ورودعنوان ژورنال:
- Organic letters
دوره 7 25 شماره
صفحات -
تاریخ انتشار 2005